NOD / SCID / cnull mouse : an excellent recipient mouse model for engraftment of human cells
نویسندگان
چکیده
c null mice and NOD/Shi-scid mice. When human CD34 cells from umbilical cord blood were transplanted into this strain, the engraftment rate in the peripheral circulation, spleen, and bone marrow were significantly higher than that in NOD/Shiscid mice treated with anti-asialo GM1 antibody or in the 2-microglobulin– deficient NOD/LtSz-scid (NOD/SCID/ 2mnull) mice, which were as completely defective in NK cell activity as NOD/SCID/
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